South Tipperary General Hospital is a 255 Bed hospital providing acute services for the South Tipperary population of 86,000 people (2006 census). South Tipperary General Hospital also provides services to the bordering areas of North Tipperary and West Waterford increasing the catchment area up to 135,000.

Until January 2007 Acute Hospital Services in South Tipperary were provided on two sites; – South Tipperary General Hospital (STGH), Clonmel and Our Lady's Hospital (OLHC), Cashel. A historic agreement for the development of health services in South Tipperary was signed in 1996 between the Cashel Hospital Action Committee and the former South Eastern Health Board.

Acute hospital services in South Tipperary amalgamated in South Tipperary General Hospital, Clonmel on January 12th 2007 following a major capital development to facilitate the transfer of A&E, General Surgery and Oncology services from Our Lady's Hospital, Cashel to Clonmel. (Cost €30m)

A number of outreach outpatient clinics, radiology services and a Minor Injuries Unit remain operational at Our Lady's Hospital Cashel in accordance with the terms of the 1996 agreement. It is also planned to open PCCC services on the Cashel site in April 2007 (Alzheimer's, Mental Health and Disability Units).

The Obstetric Department, South Tipperary General Hospital provides outreach clinics in both Thurles and Tipperary Town.

South Tipperary General Hospital signed a learning agreement with University College Cork in 2006 for the education of Medical Students; approval is awaited for teaching hospital status from the Department of Health and Children.